ABSTRACT
Objective To investigate the effects of breviscapine on the expression of urine Kim‐1 and NGAL in the patients with septic shock complicating renal injury .Methods A total of 66 cases patients with septic shock complicating acute kidney inju‐ry(AKI) in our hospital from May 2013 to May 2015 were selected and randomly divided into the intervention group and control group according to the random number table ,33 cases in each group .All cases were given the standardized therapy of septic shock . On this basis the intervention group was given the intravenous drip of breviscapine .The clinical curative effects were compared be‐tween the two groups .Results The level of Kim‐1 and NAGL were risen after 1 d of treatment ,but began to gradually drop on 3 d of treatment ,the levels of Kim‐1 and NAGL on 3 ,5 ,7 ,9 d had statistical differences between the two groups (P<0 .05);in the in‐tervention group ,5 cases died ,while 6 cases in the control group died .The ICU stay time ,cases number needing dialysis ,dialysis times and dialysis curative time in the control group were more than those in the intervention group ,the differences were statistical‐ly significant(P< 0 .05) .Conclusion Breviscapine could reduce the expression of Kim‐1 and NGAL in the patients with septic shock complicating AKI and promote the recovery of renal function .